A Breakthrough in Proactive
Cardiovascular Care
A Smarter Way to Support Heart Health –
Without (Or Before) the Meds
The Zona Plus device provides cardiovascular conditioning “in the palm of your hand,” using personalized isometric exercise to strengthen vascular health.
Zona Plus is a Class I FDA-cleared isometric exercise device backed by decades of research. It’s a handheld, biofeedback-guided system that triggers nitric oxide production, improves endothelial function, and helps the body regulate blood pressure naturally. For patients who aren’t ready for medication – or are tired of side effects – Zona offers a proactive, non-invasive alternative that works with the body, not against it. As one practitioner described it, “Zona is like resistance training for your arteries – in just 12 minutes a day.”
Why Practitioners Trust Zona:
FDA-cleared as a Class I powered exercise device –
intended for adjunctive use in managing cardiovascular fitness.
Backed by 20+ years of research –
born from Air Force studies in the 1980s and refined through decades of clinical trials.
Proven isometric science –
handgrip training can significantly lower resting blood pressure, often matching or exceeding the effects of standard aerobic exercise or a single antihypertensive medication.
Drug-free with zero side effects –
no prescriptions or pills required. Patients gain health benefits without the downside of medications (no fatigue, no dizziness – just results).
Trusted by doctors, athletes, and biohackers –
used by top clinicians and wellness experts who demand evidence and efficacy.
Early Intervention Matters –
Don’t Wait for Disease
“No responsible healthcare provider ignores
early intervention.”
Mark Young, CEO of Zona Health
Empowering patients with a lifestyle-based, preventive approach can change their trajectory. Zona fits perfectly into a root-cause, longevity-focused practice: it’s non-invasive, easy to use at home, and encourages patients to take an active role in their cardiovascular health. Rather than simply telling patients to “wait and see” or start a drug, you can offer Zona as a way to strengthen their cardiovascular system now and potentially avoid disease progression down the road.
Backed by Science & Clinical Evidence (For Your Eyes Only)
We speak carefully in public due to regulations, but here’s the truth: Zona Plus isn’t just theory – it’s backed by solid science. In fact, isometric handgrip training has been studied for decades and shown remarkable results in improving blood pressure and vascular health. Multiple clinical trials report significant drops in systolic blood pressure (often 10–15+ mmHg reductions in 4–8 weeks) along with improvements in vessel function. This drug-free therapy even helped resistant hypertensive patients who weren’t responding to medications. It’s one of the most potent lifestyle interventions for hypertension available – which is why the American Heart Association has acknowledged its efficacy in recent guidelines.
Key physiological benefits demonstrated by research include:
- Reduced Blood Pressure: Studies show an average ~12 mmHg drop in systolic BP after just 4–8 weeks of Zona-guided training – comparable to adding a first-line hypertension drug, but achieved naturally.
- Improved Endothelial Function: Isometric exercise “re-tunes” the endothelium (the lining of blood vessels) to dilate more easily. One study noted a 180% improvement in artery dilation (flow-mediated dilation increased from ~1.6% to 4.5% in 8 weeks), indicating healthier, more responsive blood vessels.
- Nitric Oxide Release: The handgrip protocol activates nitric oxide synthase, boosting NO levels. Nitric oxide is a potent vasodilator – more NO means arteries relax and blood flows with less resistance, naturally lowering pressure.
- Autonomic Nervous System Balance: Regular isometric training shifts the autonomic balance toward parasympathetic (vagal) dominance, reducing harmful sympathetic drive. In simple terms, Zona helps recalibrate the body’s blood pressure reflexes, leading to better heart rate variability and more stable BP control.
FDA Status: Zona Plus is FDA-cleared as a Class I exercise device – safe for home use. We are currently in FDA-supervised clinical trials aiming to secure full approval to market Zona for blood pressure reduction claims. (Until those trials are completed, we provide the detailed results only to healthcare professionals.)
Explore the Clinical Evidence Hub
We’ve compiled decades of research, white papers, and emerging trial data in one place for practitioners. Due to regulatory limits, these materials are gated for verified providers only. Sign in to review the studies behind Zona’s efficacy, including summaries of key trials (via isometricstudies.com) and our ongoing clinical results. Get the data you need to make an informed decision.
Beyond the Sodium Myth: Addressing Root Causes of Hypertension
Most patients have heard “cut down on salt” as the answer to high blood pressure. Yet we know hypertension is far more nuanced. It was never just about sodium. Modern research highlights other root factors: potassium deficiency, chronic nitric oxide depletion, prolonged stress, insulin resistance, and endothelial dysfunction all play a role. Simply put, high blood pressure often results from a breakdown in the body’s ability to relax and regulate blood vessel tone.
Zona’s isometric therapy targets that root cause system – the endothelium and vascular function – rather than just masking symptoms. By boosting nitric oxide and improving endothelial responsiveness, Zona helps restore the natural mechanism your body uses to control blood pressure. It’s a holistic, physiology-first approach: instead of blaming patients for salt, we empower them to strengthen their vessels and autonomic balance. The result is better blood pressure resilience and long-term cardiovascular health. (For a deeper dive into hypertension’s true causes and solutions, check out bpexercise.org.)
Join the Network of
Top Practitioners & Influencers
Zona is trusted by forward-thinking voices in functional and integrative health because they believe in root-cause medicine and smarter interventions. Join the growing community of practitioners – including well-known influencers like Dave Asprey, Dr. Josh Axe, Luke Storey, Dr. Motley, Ben Azadi, Natalie Niddam, and others – who have integrated Zona into their wellness arsenal. They’ve seen firsthand how this device helps patients take control of their cardiovascular health in a simple, effective way.
“You must try the Zona Plus.”
– Dave Asprey, Author / Founder of Bulletproof Executive
Nat Niddam
Luke Storey
Host of The Life Stylist Podcast
Dr. Christopher Motley
Host of Ancient Health Podcast
Ben Azadi
Host of Keto Kamp Podcast
“Zona is one of the smartest tools for heart health I’ve ever seen.”
— Feedback from a leading integrative physician
When you become a Zona affiliate partner, you’re not alone – you’ll be part of an expert network that’s transforming preventive care. We provide all the support and resources you need to succeed, including:
Patient Discounts: You’ll get a personalized coupon code to give your patients $50 off their Zona Plus purchase – a win-win that motivates patients to act on your recommendation.
Generous Referral Commission
Earn $150 for every patient you refer who purchases a Zona Plus with your unique code. It’s a lucrative way to add passive income while recommending a product you believe in.
Patient Discounts
You’ll get a personalized coupon code to give your patients $50 off their Zona Plus purchase – a win-win that motivates patients to act on your recommendation.
High-Converting Tools
Access an affiliate dashboard to track referrals and payouts, plus ready-to-use educational materials, videos, and even a personal landing page to help explain Zona to patients. We’ve done the heavy lifting creating marketing assets that convert, so you can focus on patient care.
Dedicated Support
Our team is here to assist with any clinical questions or affiliate help you need. Consider us an extension of your staff when it comes to leveraging Zona for your practice.
Ready to elevate your practice with a cutting-edge solution? Join the practitioners who are already using Zona to change lives and position yourself as a leader in proactive cardiovascular care.
A Message from Our CEO –
Why We Need You
Practitioner Testimonials and Case Studies (Coming Soon)
Real-world results drive confidence. We’re compiling powerful case studies and testimonials from practitioners like you who have seen success with Zona Plus in their patient population. Stay tuned for featured stories such as:
- Dr. Jane Smith, ND, on how 12 of her pre-hypertensive patients avoided needing medications by using Zona for 8 weeks.
- Dr. John Doe, DC, integrating Zona into his chiropractic wellness program and seeing patients report improved blood pressure and energy levels.
- A clinical case series from an integrative clinic where Zona Plus usage led to an average 15 mmHg blood pressure drop in difficult cases.
These peer insights will be available soon in our Clinical Evidence Hub. Your story could be next – when you observe amazing outcomes with your patients, we’d love to feature your experience to inspire others. (If you’re already using Zona in your practice and have a success story, let us know!)
FAQ – Still Have Questions?
Is Zona Plus FDA approved?
Zona Plus is FDA-cleared as a Class I powered exercise device. In other words, the FDA recognizes it as a safe exercise tool for improving cardiovascular fitness. We are currently in clinical trials to obtain full FDA approval for specific blood pressure-lowering indications, but practitioners and patients are already using Zona safely under the general wellness umbrella.
How does it actually work to lower blood pressure?
Zona Plus guides the user through isometric handgrip exercises with real-time biofeedback. By squeezing the device at a prescribed pressure, it stimulates physiological responses – increased nitric oxide, improved endothelial function, and a balanced autonomic nervous system – that help the body lower and regulate blood pressure naturally. The protocol is just 12 minutes, five days a week. It’s like a personalized workout for your vascular system, optimizing the squeeze-and-release reflex that keeps arteries flexible and pressure in check.
Who can become a Zona affiliate?
If you’re a licensed or credentialed healthcare provider who sees patients (MD, DO, ND, DC, NP, PA, RN, LAc, functional medicine practitioner, etc.), you likely qualify to join the program. We welcome practitioners across conventional and alternative disciplines – the key is you’re committed to proactive patient care. There’s no cost to join, and we provide all the training and support to get you started quickly.
What support will I get as an affiliate?
As a Zona affiliate, you’ll have direct access to our team for product questions, an online dashboard to monitor your commissions, and a library of ready-made content (brochures, videos, FAQs) to share with patients. We want you to succeed – our affiliate manager is just an email or call away if you need anything, from clinical data to marketing tips.
Where can I learn more about the science behind Zona?
Visit our Clinical Evidence Hub for a curated collection of research papers, clinical trial results, and explanatory articles. We also recommend bpexercise.org as a trusted resource for in-depth articles on emerging cardiovascular research and isometric exercise science. And of course, feel free to reach out to us – we’re happy to discuss the science one-on-one and provide reference materials.
Ready to transform your
practice and your patients’ health?
Zona is more than a device – it’s a movement toward preventative, empowered care. If you’re tired of the “wait until it’s bad, then medicate” model, we invite you to join us in making a change. Help your patients take control of their blood pressure naturally, and enjoy a new revenue stream for your practice as a bonus. It’s not often that doing good for patients and doing well for your business go hand-in-hand. With Zona’s affiliate program, you can achieve both.
Apply now to become a Zona Practitioner Affiliate and lead the future of heart health.